Live Stream: Anthony Joshua Vs. Kubrat Pulev DAZN Weigh In

Boxing Fight Team : Kubrat Pulev vs Anthony Joshua Live/Repeat:Live Kubrat Pulev vs Anthony Joshua Live Stream Unified Heavyweight Champion of the World Anthony Joshua OBE will defend his IBF, WBA, WBO, and IBO World

Live Stream ➤➤

Live Stream ➤➤

Boxing Fight Team : Kubrat Pulev vs Anthony Joshua Live/Repeat:Live Kubrat Pulev vs Anthony Joshua Live Stream Unified Heavyweight Champion of the World Anthony Joshua OBE will defend his IBF, WBA, WBO, and IBO World Titles against Mandatory Challenger Kubrat Pulev at The O2 in London on Saturday, December 12, live on Sky Sports Box Office in the UK and on DAZN. When and Where is Joshua vs Pulev Fight? The bout takes place on Saturday, December 12, the same day in history that James ‘Bonecrusher’ Smith knocked out Tim Witherspoon in the first round at Madison Square Garden to become WBA World heavyweight champion. It takes place behind closed doors at the O2 Arena in London, although promoter Eddie Hearn is hopeful that some kind of crowd will be allowed to attend, with some venues permitted a proposed 25% capacity. Anthony Joshua v Kubrat Pulev undercard More fights will be added to the slate in the coming days, but for now, fans can look forward to the following Joshua v Pulev undercard: Lawrence Okolie v Krzysztof Głowacki Martin Bakole v Sergei Kuzmin ]Hughie Fury v Mariusz Wach Joshua vs Pulev Fight TV channel and PPV live streaming info? The fight will be shown live on Sky Sports Box Office for £24.95. Sky’s coverage will start at 7 pm ahead of a stacked undercard. You don’t have to be a Sky customer to watch the fight — you can live stream for the same price on your computer, mobile, and tablet devices. Sky Sports Box Office will also be available on BT TV. There are two ways to make the purchase — by tuning to channel 496 or by searching for the event in the BT Player.

Recent announcements from COVID-19 vaccine trials have sparked much interest and excitement. The first two vaccines announced from Pfizer/BioNTech and Moderna are mRNA vaccines, whereas the third potential candidate finishing up late-stage clinical trials is a viral vector vaccine from Oxford/AstraZeneca. Pfizer’s vaccine has been granted emergency approval in the UK and Canada, and it is very likely that it will gain this approval in the US today. Many other vaccines are in clinical trials and will likely be announcing results soon.

Although these announcements have generated much excitement, there is a significant portion of the population that is hesitant to get excited about the possibility of a vaccine. Reasons for this hesitation range from concerns about the short time spent in clinical trials to concerns about what the vaccines contain.

I am a virologist. I also tend to lean fairly conservative (whatever that means anymore) when it comes to many political issues. Since the majority of vaccine concerns are being voiced by conservatives, I wanted to take a minute to explain my perspective on getting the COVID-19 vaccine and why I plan on getting it when it becomes available. Most of this article will focus on the new mRNA vaccines as they are the leading candidates at the moment, but I will reference other vaccine platforms when relevant.

If you have concerns about whether or not you should get the vaccine, I hope these thoughts will help you as you think through that decision.

The vaccine is effective

I plan on getting the vaccine because the clinical trial data shows that they will protect against the virus.

Perhaps some of the most anticipated and exciting news about the COVID-19 vaccines in development is that they appear to be highly effective. This is the case for the two leading mRNA vaccines, at least. Pfizer announced that their vaccine was 95% effective against COVID-19 in their phase III clinical trials. The graph (figure 13 on page 58 of the report submitted to the FDA) showing cumulative COVID-19 cases in the vaccine and placebo groups, respectively, is about as clean and clear as you can get in a phase III clinical trial, showing a stark and definitive protective effect in the vaccine group.

Similarly, Moderna announced that their vaccine is 94.1% effective. These are very promising numbers. AstraZeneca was the third company to announce an effective vaccine, with one dosing regimen showing 62% effectiveness and another regimen showing 90% effectiveness. For comparison, the seasonal flu vaccine is typically 40–60% effective each year (this is in part due to the nature of the influenza virus compared to coronaviruses).

To be fair, these efficacy numbers are specific to the clinical trials environment. In the real world, vaccine effectiveness might be lower. However, these data showing very high vaccine effectiveness suggests that these vaccines work well and will protect a significant number of people. I would guess that efficacy rates in the wild will be quite similar to those reported above, if just slightly lower.

The vaccine is safe

I plan on getting the vaccine because all signs point to the vaccine being safe.

The two leading vaccines from Pfizer and Moderna are mRNA-based. mRNA is a natural molecule in our own cells, taking instructions coded in our DNA and presenting that information to proteins called ribosomes, which build proteins from the mRNA instruction. Coronavirus mRNA vaccines contain instructions that tell your cells how to make a Sars-CoV-2 (the virus that causes COVID-19) protein that is typically found on the outside of the virus. Your cells then take these instructions and make the protein, which they then present to your immune cells to recognize and make antibodies towards (this is an over-simplified explanation, but it serves our purposes).

This is actually what would happen in a normal infection, except in a normal infection, the virus would introduce instructions for your cells to make all the viral proteins instead of just the one that the vaccine has. There is therefore no possibility of infection from mRNA vaccines, because there are no instructions to make all the necessary virus components. Further, mRNA is an inherently unstable molecule, meaning that it will degrade rather quickly (and thus not stay in our cells for very long), and it cannot change our cell’s DNA. This rationale is why mRNA vaccines are considered very safe.

But do we really know that these vaccines are safe? They’ve only been in trials for a few months, and vaccines normally spend years in clinical trials, right?

From years of vaccine research, we have a good understanding of vaccines and how they work in the body, so we have a good idea of what to be looking out for as far as adverse events or side effects, both severe and non-severe. For example, typical non-severe or minor adverse events often include pain, redness, and swelling at the injection site, fever, fatigue, and headache. These symptoms have been noted in the COVID-19 vaccine trials, and although they may be uncomfortable, they usually resolve within a few days. Severe adverse events that have been seen with other vaccines include seizures, anaphylaxis, and Guillian-Barré Syndrome (note that GBS, the adverse effect with the most potential to have long lasting effects, has a prevalence of between 6 and 40 cases per 1 million people in the US, and being sick with diarrhea, lung, or sinus issues poses a greater risk for developing GBS than vaccines). We also know that typically these symptoms develop within days to months, not years down the road.

While this is the first mRNA vaccine to be approved, there are several reasons to be confident in the safety of these vaccines. As explained above, the theoretical basis for mRNA vaccines gives every indication that they will be safe and not cause serious adverse effects. Further, mRNA vaccines have been in development for several years for other infectious diseases, such as influenza, and clinical trials had already begun.

COVID-19 vaccine trials are also under intense scrutiny, as the whole world is watching for obvious reasons (for example, Oxford’s vaccine trial results have generated questions and concerns from the scientific community). Independent review boards are being used to review the results to eliminate as much bias as possible.

Moderna has enrolled 30,000 participants and Pfizer nearly 44,000, and to date, there have been no severe adverse events following immunization. The AstraZeneca vaccine trial, which also enrolled around 30,000 participants, saw one participant develop spinal cord inflammation. The trial was immediately halted until review occured, and it was determined the patient developed multiple sclerosis and there was no evidence that this was related to the COVID vaccine.

To question the speed of development and approval of these vaccines is a legitimate concern. The development of a COVID-19 has proceeded at an unprecedented pace. This is especially true for mRNA vaccines, as the mRNA vaccine platform has yet to be approved for any disease. However, this rapid development does not mean that bad science is being done. It is indeed impossible to know all the downstream effects of these new vaccines. However, there has been no evidence to warrant any fear that these vaccines will be anything other than safe. Compare that with the known detrimental effects (both short term and long term) that COVID-19 can have on the body and I believe that the risk-benefit analysis weighs heavily on the side of the vaccine.

The vaccine will allow us to reclaim our social lives

I plan on getting the vaccine because I want us all to be able to spend quality time with our friends and families again.

This year has been difficult for most of us, not only because of the pandemic but perhaps even more so because of what the pandemic has taken away from us: our social lives. I truly believe the short- and long-term mental health effects from social distancing and isolation are underappreciated as of yet. An effective vaccine holds the potential to allow us to reclaim our social lives without the fear of spreading the virus to those we love.

Although there are some concerns that a vaccine will not fully allow us to get back to normal, I believe these concerns are overstated. An effective vaccine that is widely accepted by the public will severely limit the number of people that the coronavirus can infect, which in turn will drive down viral transmission. In the best-case scenario, there will not be enough people that the virus can infect to keep it in circulation.

But even if vaccination rates are much more modest, any proportion of the population that is immune to the virus should decrease viral transmission. Not to mention the fact that especially vulnerable populations, such as the elderly and those with risk factors, will have an option for a line of protection even if the general public is less than enthusiastic about the vaccine. We cannot let perfect be the enemy of good enough.

Two common objections

These are the main reasons I am planning on getting the COVID-19 vaccine. Honestly, for many people, getting the vaccine just seems like common sense. Why wouldn’t you get the vaccine?

Yet, there are quite a few people who are hesitant to get the vaccine. And a growing number are voicing outright opposition to the vaccine. Hesitancy that spawns from uncertainty about the safety of a new vaccine is reasonable, though there is good reason to believe that the vaccine will be both safe and effective. However, there are a couple of claims that are making their rounds that are misleading people about the vaccine, causing unwarranted fear and opposition to the vaccine. This article would not be complete if I didn’t address these concerns.